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Multimodal Imaging: Unveiling Biological Secrets with AFM, Confocal, and Raman Techniques
Explore the power of combining Atomic Force Microscopy (AFM) with Confocal and Raman microscopy to achieve high-resolution topographical maps and detailed biochemical insights in biological samples, all within physiologically relevant environments.
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Prompt
AFM – generally As an standalone device - is utilisedn mainly for obtaining high resolution topographical maps and to acquire mechanical properties of biological samples. However the versatility of this technique is enhanced by Combination with other techniques/tools . The combination with other techniques allos multimodal characteristics. Theo ne region of interested is characterised by two techniques at the same time. – time efficient, cross Confocal microscopy The most used in life sciences. Thanks to the fluorescence the biochemical proceses can be spatialy visualised. – multimodal characteristics in the physiological enviroment Raman microscope complements this by producing both rich, detailed, chemical images and highly specific Raman data from discrete points no need for moving the sample – correlation imaging;Bruker Dimension Icon Raman https://www.renishaw.com/it/37345.aspx SEM AFM topography can be combined with different channels of SEM – BSE, SE.. Precise navigation of the sensor in SEM view thanks to the tip-tilt Biologically relevant conditions – in the case of ESEM mode Fluid FM The AFM tip is used as a nanoneedle or nanopipette Treatment can be directly injected into cell/ or single cell liquid can be uzsed for analysis.
